Increasing power for voxel-wise genome-wide association studies: the random field theory, least square kernel machines and fast permutation procedures.

Abstract excerpt

Imaging traits are thought to have more direct links to genetic variation than diagnostic measures based on cognitive or clinical assessments and provide a powerful substrate to examine the influence of genetics on human brains. Although imaging genetics has attracted growing attention and interest, most brain-wide genome-wide association studies focus on voxel-wise single-locus approaches, without taking...

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