Article
Exhaustive search of the SNP-sNP interactome identifies epistatic effects on brain volume in two cohorts.
Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention - 1 Jan 2013
Hibar Derrek P, Stein Jason L, Jahanshad Neda, Kohannim Omid, Toga Arthur W, McMahon Katie L, de Zubicaray Greig I, Montgomery Grant W, Martin Nicholas G, Wright Margaret J, Weiner Michael W, Thompson Paul M
Abstract excerpt
The SNP-SNP interactome has rarely been explored in the context of neuroimaging genetics mainly due to the complexity of conducting approximately 10(11) pairwise statistical tests. However, recent advances in machine learning, specifically the iterative sure independence screening (SIS) method, have enabled the analysis of datasets where the number of predictors is much larger than the number of observations....
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