Article

Upstream open reading frame inactivation augments GATA4 translation and cardiomyocyte hypertrophy in mice

2025-05-18

Abstract excerpt

Upstream open reading frames (uORFs) are short peptide-encoding sequences located in the 5’ untranslated region (5’ UTR) of mRNAs, enabling translational repression of main (m)ORFs. While uORFs are found in ∼50% of mRNAs in humans, our understanding of their biological function remains limited. This study aims to elucidate the role of the uORF in the 5’ UTR of the Gata4 (GATA binding protein 4) gene in cardiac bio...

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Literature Corpus work: c3600342-4e73-5fca-bd36-f41a658fa107
DOI: 10.1101/2025.05.18.654700

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