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Article

An upstream open reading frame impedes translation of the huntingtin gene.

Nucleic acids research - 1 Dec 2002

Lee Joseph, Park Eun Hee, Couture Graeme, Harvey Isabelle, Garneau Philippe, Pelletier Jerry

Abstract excerpt

Expansion of a CAG tract within the huntingtin gene, leading to the production of a protein with an expanded polyglutamine tract, is responsible for Huntington's disease. We show here that the 5' untranslated region (UTR) of the huntingtin gene plays an important role in controlling the synthesis of huntingtin. In particular, the 5' UTR contains an upstream open reading frame (uORF) encoding a 21 amino acid...

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Identifiers

PMID: 12466534
DOI: 10.1093/nar/gkf664
PMCID: PMC137975

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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