Article

Targeted BDNF upregulation via upstream open reading frame disruption

2025-03-10

Abstract excerpt

To understand the relative contributions of 5ʹ UTR elements to translation, we performed a comprehensive analysis of upstream open reading frames (uORFs) across a representative 5ʹ UTR. We selected the neurotrophin BDNF (Brain derived neurotrophic factor) as an exemplar as upregulation of this protein is a potential therapeutic approach for a plethora of neurodevelopmental, neurodegenerative, and neuropsychiatric...

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Literature Corpus work: 702beed7-74f5-5865-8d83-21632bbd9d8a
DOI: 10.1101/2025.03.04.641482

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