Article

Secondary structures that regulate mRNA translation provide insights for ASO-mediated modulation of cardiac hypertrophy

2023-06-15

Abstract excerpt

Translation of upstream open reading frames (uORFs) typically abrogates translation of main (m)ORFs. The molecular mechanism of uORF regulation in cells is not well understood. Here, we identified a double-stranded RNA (dsRNA) structure residing within the GATA4 uORF that augments uORF translation and inhibits mORF translation. Antisense oligonucleotides (ASOs) that disrupt this dsRNA structure promote mORF trans...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1da6f8cf-bd7b-5e11-bb0c-7a57bc0dfe22
DOI: 10.1101/2023.06.15.545153

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Secondary structures that regulate mRNA translation provide insights for ASO-mediated modulation of cardiac hypertrophyDOI 10.1101/2023.06.15.545153Read

Upstream open reading frame inactivation augments GATA4 translation and cardiomyocyte hypertrophy in miceSemantic proximity Read

Translational control of cardiac fibrosisSemantic proximity Read

Comprehensive analysis of nonsense-mediated mRNA decay targets and activity in cardiomyocytesSemantic proximity Read

RNA Therapeutics – The Next Generation of Drugs for Cardiovascular DiseasesSemantic proximity Read

Circular RNA circRNA_000203 aggravates cardiac hypertrophy via suppressing miR-26b-5p and miR-140-3p binding to Gata4Semantic proximity Read

Widespread Translational Control of Fibrosis in the Human Heart by RNA-Binding ProteinsSemantic proximity Read

Circular RNA circFTO promotes pressure overload-induced cardiac hypertrophy via encoding a novel protein FTO-36aaSemantic proximity Read

uORF-targeting steric block antisense oligonucleotides do not reproducibly activate RNASEH1 expressionSemantic proximity Read

RNA G-quadruplexes mark repressive upstream open reading frames in human mRNAsSemantic proximity Read

Translational Control in Cardiac Pathophysiology and Therapeutic Development: When mRNA Meets the HeartSemantic proximity Read

5′-UTR G-Quadruplex-Mediated Translation Regulation in Eukaryotes: Current Understanding and Methodological ChallengesSemantic proximity Read

uORFdb--a comprehensive literature database on eukaryotic uORF biology.Semantic proximity Read