Article
Endothelial nitric oxide synthase gene intron 4 VNTR polymorphism in sickle cell disease: relation to vasculopathy and disease severity.
Pediatric blood & cancer - 1 Mar 2015
Tantawy Azza Abdel Gawad, Adly Amira Abdel Moneam, Ismail Eman Abdel Rahman, Aly Shereen Hussiny
Abstract excerpt
BACKGROUND: Impaired NO bioavailability represents the central feature of endothelial dysfunction, and is a common denominator in the pathogenesis of vasculopathy in sickle cell disease (SCD). Evidence indicates the contribution of 4a allele of endothelial NO synthase (eNOS) gene to cardiac and renal diseases. We studied the 27-base pair tandem repeat polymorphism in intron 4 of eNOS gene in 51 patients with SCD...
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