Article
Association of endothelial nitric oxide synthase gene intron 4 polymorphism with end-stage renal disease.
Nephrology (Carlton, Vic.) - 1 Jun 2007
Bellini Maria H, Figueira Márcia N, Piccoli Michelly F, Marumo Júlio T, Cendoroglo Maysa S, Neto Miguel C, Dalboni Maria A, Batista Marcelo C, Goes Miguel A, Schor Nestor
Abstract excerpt
BACKGROUND: Nitric oxide (NO) released from endothelial cells is related to the maintenance of physiological vascular tone. The impairment of endothelial NO generation brought about by gene polymorphism is considered one of the deterioration factors in progressive renal disease. In the endothelial nitric oxide synthase (eNOS) intron 4 polymorphism, the presence of the aa genotype has been associated with...
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