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Article

Endothelial nitric oxide synthase gene polymorphism is associated with sickle cell disease patients in India.

Journal of human genetics - 1 Dec 2013

Nishank Sudhansu Sekhar, Singh Mendi Prema Shyam Sunder, Yadav Rajiv, Gupta Rasik Bihari, Gadge Vijay Sadashiv, Gwal Anil

Abstract excerpt

Patients with sickle cell disease (SCD) produce significantly low levels of plasma nitric oxide (NO) during acute vaso-occlusive crisis. In transgenic sickle cell mice, NO synthesized by endothelial nitric oxide synthase (eNOS) enzyme of vascular endothelial cells has been found to protect the mice from vaso-occlusive events. Therefore, the present study aims to explore possible association of eNOS gene...

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Identifiers

PMID: 24088668
DOI: 10.1038/jhg.2013.99

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SCD

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