Article
Endothelial Nitric Oxide Synthase (eNOS) Gene Polymorphisms and Markers of Hemolysis, Inflammation and Endothelial Dysfunction in Brazilian Sickle Cell Anemia Patients.
Biochemical genetics - 1 Aug 2020
Chenou F, Albuquerque D M, Leonardo D P, Domingos I F, Bezerra M A C, Araújo A S, Blotta M H S L, Costa F F, Sonati M F, Paula E V, Santos M N N
Abstract excerpt
The impaired bioavailability of endogenous nitric oxide (NO) in sickle cell anemia (SCA) may be influenced by polymorphisms in the endothelial nitric oxide synthase gene (eNOS). We compared allelic/genotypic frequencies of the eNOS polymorphisms T-786C, VNTR4a/b and G894T between 89 adult SCA patients and 100 healthy controls, and investigated the relationship between these SNPs and markers of hemolysis [lactate...
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