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Article

Loss of the mono-allelic control of the VSG expression sites during the development of Trypanosoma brucei in the bloodstream.

Molecular microbiology - 1 Mar 2004

Amiguet-Vercher Amelia, Pérez-Morga David, Pays Annette, Poelvoorde Philippe, Van Xong Huang, Tebabi Patricia, Vanhamme Luc, Pays Etienne

Abstract excerpt

Transcription of the variant surface glycoprotein (VSG) gene of Trypanosoma brucei occurs in a single of multiple polycistronic expression sites (ESs). Analysis of RNA from proliferative long slender (LS) bloodstream forms demonstrated that initiation of transcription occurs in different ESs, but inefficient RNA processing and elongation is linked to RNA polymerase arrest in all except one unit at a time. The...

Topics

Alleles
Animals
Antigenic Variation
Base Sequence
DNA, Protozoan
Gene Expression Regulation
Genes, Protozoan
Molecular Sequence Data
RNA, Messenger
RNA, Protozoan

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transcription, Genetic

Trypanosoma brucei brucei

Trypanosomiasis, African

Variant Surface Glycoproteins, Trypanosoma

Source

Identifiers

PMID: 15009886
DOI: 10.1111/j.1365-2958.2003.03937.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Loss of the mono-allelic control of the VSG expression sites during the development of Trypanosoma brucei in the bloodstream.PMID 15009886Read ↗

Transcription is initiated on silent variant surface glycoprotein expression sites despite monoallelic expression in Trypanosoma brucei.Semantic proximity Read ↗

Mono-allelic VSG expression by RNA polymerase I in Trypanosoma brucei: expression site control from both ends?Semantic proximity Read ↗

Differential RNA elongation controls the variant surface glycoprotein gene expression sites of Trypanosoma brucei.Semantic proximity Read ↗

Control of gene expression in trypanosomes.Semantic proximity Read ↗

Control of gene expression in trypanosomesSemantic proximity Read ↗

Cytokinesis of Trypanosoma brucei bloodstream forms depends on expression of adenylyl cyclases of the ESAG4 or ESAG4‐like subfamilySemantic proximity Read ↗

Promoter occupancy of the basal class I transcription factor A differs strongly between active and silent VSG expression sites in Trypanosoma bruceiSemantic proximity Read ↗

Chromatin remodelling during the life cycle of trypanosomatids.Semantic proximity Read ↗

Metacyclic VSG expression site promoters are recognized by the same general transcription factor that is required for RNA polymerase I transcription of bloodstream expression sites.Semantic proximity Read ↗

Nuclear repositioning of the <i>VSG</i> promoter during developmental silencing in <i>Trypanosoma brucei</i>Semantic proximity Read ↗

High-resolution analysis of multi-copy variant surface glycoprotein gene expression sites in African trypanosomesSemantic proximity Read ↗

Delineation of the regulated Variant Surface Glycoprotein gene expression site domain of Trypanosoma brucei.Semantic proximity Read ↗

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