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High-resolution analysis of multi-copy variant surface glycoprotein gene expression sites in African trypanosomes

18 Oct 2016

Abstract excerpt

BACKGROUND: African trypanosomes cause lethal diseases in humans and animals and escape host immune attack by switching the expression of Variant Surface Glycoprotein (VSG) genes. The expressed VSGs are located at the ends of telomeric, polycistronic transcription units known as VSG expression sites (VSG-ESs). Each cell has many VSG-ESs but only one is transcribed in bloodstream-form parasites and all of them are...

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PMID: 27756224
DOI: 10.1186/s12864-016-3154-8

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