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Article

Transcription is initiated on silent variant surface glycoprotein expression sites despite monoallelic expression in Trypanosoma brucei.

Proceedings of the National Academy of Sciences of the United States of America - 17 Jun 2014

Kassem Ali, Pays Etienne, Vanhamme Luc

Abstract excerpt

African trypanosomes survive the immune defense of their hosts by regularly changing their antigenic coat made of variant surface glycoprotein (VSG). The Trypanosoma brucei genome contains more than 1,000 VSG genes. To be expressed, a given VSG gene must be located in one of 15 telomeric regions termed "VSG expression sites" (ESs), each of which contains a polycistronic transcription unit that includes...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24889641
DOI: 10.1073/pnas.1404873111
PMCID: PMC4066500

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Transcription is initiated on silent variant surface glycoprotein expression sites despite monoallelic expression in Trypanosoma brucei.PMID 24889641Read ↗

Mono-allelic VSG expression by RNA polymerase I in Trypanosoma brucei: expression site control from both ends?Semantic proximity Read ↗

Loss of the mono-allelic control of the VSG expression sites during the development of Trypanosoma brucei in the bloodstream.Semantic proximity Read ↗

Monoallelic antigen expression in trypanosomes requires a stage-specific transcription activatorSemantic proximity Read ↗

Stage-specific transcription activator ESB1 regulates monoallelic antigen expression in Trypanosoma bruceiSemantic proximity Read ↗

Metacyclic VSG expression site promoters are recognized by the same general transcription factor that is required for RNA polymerase I transcription of bloodstream expression sites.Semantic proximity Read ↗

Promoter occupancy of the basal class I transcription factor A differs strongly between active and silent VSG expression sites in Trypanosoma bruceiSemantic proximity Read ↗

Differential RNA elongation controls the variant surface glycoprotein gene expression sites of Trypanosoma brucei.Semantic proximity Read ↗

High-resolution analysis of multi-copy variant surface glycoprotein gene expression sites in African trypanosomesSemantic proximity Read ↗

Antigenic variation in A frican trypanosomes: the importance of chromosomal and nuclear context in VSG expression controlSemantic proximity Read ↗

Expression site attenuation mechanistically links antigenic variation and development in Trypanosoma brucei.Semantic proximity Read ↗

Delineation of the regulated Variant Surface Glycoprotein gene expression site domain of Trypanosoma brucei.Semantic proximity Read ↗

Emergence and adaptation of the cellular machinery directing antigenic variation in the African trypanosomeSemantic proximity Read ↗

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