Article
Metacyclic VSG expression site promoters are recognized by the same general transcription factor that is required for RNA polymerase I transcription of bloodstream expression sites.
Molecular and biochemical parasitology - 1 Sept 2017
Kolev Nikolay G, Günzl Arthur, Tschudi Christian
Abstract excerpt
Infectious metacyclic Trypanosoma brucei cells develop in the salivary glands of tsetse flies. A critical aspect of the developmental program leading to acquisition of infectivity is the synthesis of a variant surface glycoprotein (VSG) coat. Metacyclic VSG genes are transcribed from a set of specialized VSG expression sites (ESs) that differ from bloodstream VSG ESs by being monocistronic, being significantly...
Topics
- Base Sequence
- Binding Sites
- Gene Expression Regulation
- Mutation
- Nucleotide Motifs
- Promoter Regions, Genetic
- Protein Binding
- RNA Polymerase I
- Transcription Factors
- Transcription, Genetic
- Trypanosoma brucei brucei
- Variant Surface Glycoproteins, Trypanosoma