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Article

The ATG16L1-T300A allele impairs clearance of pathosymbionts in the inflamed ileal mucosa of Crohn's disease patients.

Gut - 1 Oct 2015

Sadaghian Sadabad Mehdi, Regeling Anouk, de Goffau Marcus C, Blokzijl Tjasso, Weersma Rinse K, Penders John, Faber Klaas Nico, Harmsen Hermie J M, Dijkstra Gerard

Abstract excerpt

OBJECTIVE: Crohn's disease (CD) is caused by a complex interplay among genetic, microbial and environmental factors. ATG16L1 is an important genetic factor involved in innate immunity, including autophagy and phagocytosis of microbial components from the gut. We investigated the effect of inflammation on the composition of microbiota in the ileal mucosa of CD patients in relation to the ATG16L1 risk status....

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Identifiers

PMID: 25253126
DOI: 10.1136/gutjnl-2014-307289

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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