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Article

Is there a role for Crohn's disease-associated autophagy genes ATG16L1 and IRGM in formation of granulomas?

European journal of gastroenterology & hepatology - 1 Aug 2010

Wolfkamp Simone C, Te Velde Anje A, Weersma Rinse K, Ponsioen Cyriel Y, Stokkers Pieter C

Abstract excerpt

OBJECTIVE: Autophagy-related 16-like 1 gene (ATG16L1) and immunity-related guanosine triphosphatase gene (IRGM) are associated with Crohn's disease susceptibility and autophagy. Elimination of invading pathogens is a function of autophagy. Formation of granulomas can be attributed to impaired recognition of bacterial components by the innate immune system. This study was undertaken to elucidate whether...

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Source

Identifiers

PMID: 20395867
DOI: 10.1097/MEG.0b013e32833775e6

Genes

IRGM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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