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Article

Genomic ATG16L1 risk allele-restricted Paneth cell ER stress in quiescent Crohn's disease.

Gut - 1 Jul 2014

Deuring J Jasper, Fuhler Gwenny M, Konstantinov Sergey R, Peppelenbosch Maikel P, Kuipers Ernst J, de Haar Colin, van der Woude C Janneke

Abstract excerpt

OBJECTIVE: Although genome wide association studies have partly uncovered the genetic basis of Crohn's disease (CD), it remains a challenge to link genetic polymorphisms to functional intestinal phenotypes. Paneth cells are specialised antimicrobial epithelial cells localised to the small-intestinal crypt-base. Here, we investigate whether genomic variations in ATG16L1 affect Paneth cell function. DESIGN: Genomic...

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Source

Identifiers

PMID: 23964099
DOI: 10.1136/gutjnl-2012-303527

Genes

PHLDA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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