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Article

IBD-Associated Atg16L1T300A Polymorphism Regulates Commensal Microbiota of the Intestine.

Frontiers in immunology - 1 Jan 2021

Liu Hongtao, Gao Ping, Jia Baoqian, Lu Na, Zhu Baoli, Zhang Fuping

Abstract excerpt

The development of inflammatory bowel disease (IBD) is driven by the interaction among host genetics, microbiota, and the immune system of the entire digestive tract. Atg16L1T300A polymorphism is a genetic factor that confers increased risk for the pathogenesis of Crohn's disease. However, the exact contributions of Atg16L1T300A to intestinal mucosal homeostasis are not well understood. Here we show that...

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Identifiers

PMID: 35154071
DOI: 10.3389/fimmu.2021.772189
PMCID: PMC8829142

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