Low frequency of TERT promoter mutations in a large cohort of gallbladder and gastric cancers

Abstract excerpt

Dear Editors, Telomerase is a ribonucleoprotein that consists of an RNA subunit and a reverse transcriptase catalytic subunit. The latter is encoded by telomerase reverse transcriptase (TERT) gene. Telomerase adds telomeric repeats to chromosome ends, thereby maintaining telomere length. It is frequently upregulated in human cancers, contributing to human tumorigenesis.1 Mutations in the TERT gene promoter have...

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