TERT promoter mutation in adult granulosa cell tumor of the ovary.

doi:10.1038/s41379-018-0007-9

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Article

TERT promoter mutation in adult granulosa cell tumor of the ovary.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jul 2018

Pilsworth Jessica A, Cochrane Dawn R, Xia Zhouchunyang, Aubert Geraldine, Färkkilä Anniina E M, Horlings Hugo M, Yanagida Satoshi, Yang Winnie, Lim Jamie L P, Wang Yi Kan, Bashashati Ali, Keul Jacqueline, Wong Adele, Norris Kevin, Brucker Sara Y, Taran Florin-Andrei, Krämer Bernhard, Staebler Annette, van Meurs Hannah, Oliva Esther, Shah Sohrab P, Kommoss Stefan, Kommoss Friedrich, Gilks C Blake, Baird Duncan M, Huntsman David G

Abstract excerpt

The telomerase reverse transcriptase (TERT) gene is highly expressed in stem cells and silenced upon differentiation. Cancer cells can attain immortality by activating TERT to maintain telomere length and telomerase activity, which is a crucial step of tumorigenesis. Two somatic mutations in the TERT promoter (C228T; C250T) have been identified as gain-of-function mutations that promote transcriptional activation...

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PMID: 29449679
DOI: 10.1038/s41379-018-0007-9

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TERT

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