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CYP2J2 Modulates Diverse Transcriptional Programs in Adult Human Cardiomyocytes

24 Mar 2020

Abstract excerpt

CYP2J2, a member of the Cytochrome P450 family of enzymes, is the most abundant epoxygenase in the heart and has multifunctional properties including bioactivation of arachidonic acid to epoxyeicosatrienoic acids, which, in turn, have been implicated in mediating several cardiovascular conditions. Using a proteomic approach, we found that CYP2J2 expression is lower in cardiac tissue from patients with...

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PMID: 32210298
DOI: 10.1038/s41598-020-62174-w

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