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Article

Suppression of Endothelial AGO1 Promotes Adipose Tissue Browning and Improves Metabolic Dysfunction.

Circulation - 28 Jul 2020

Tang Xiaofang, Miao Yifei, Luo Yingjun, Sriram Kiran, Qi Zhijie, Lin Feng-Mao, Gu Yusu, Lai Chih-Hung, Hsu Chien-Yi, Peterson Kirk L, Van Keuren-Jensen Kendall, Fueger Patrick T, Yeo Gene W, Natarajan Rama, Zhong Sheng, Chen Zhen Bouman

Abstract excerpt

BACKGROUND: Metabolic disorders such as obesity and diabetes mellitus can cause dysfunction of endothelial cells (ECs) and vascular rarefaction in adipose tissues. However, the modulatory role of ECs in adipose tissue function is not fully understood. Other than vascular endothelial growth factor-vascular endothelial growth factor receptor-mediated angiogenic signaling, little is known about the EC-derived...

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Adipose Tissue, Brown
Argonaute Proteins
Diet, High-Fat
Endothelium
Energy Metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Eukaryotic Initiation Factors

Metabolic Diseases

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PMID: 32393053
DOI: 10.1161/CIRCULATIONAHA.119.041231
PMCID: PMC7390348

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