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Article

Overexpression of endothelial nitric oxide synthase prevents diet-induced obesity and regulates adipocyte phenotype.

Circulation research - 12 Oct 2012

Sansbury Brian E, Cummins Timothy D, Tang Yunan, Hellmann Jason, Holden Candice R, Harbeson Matthew A, Chen Yang, Patel Rakesh P, Spite Matthew, Bhatnagar Aruni, Hill Bradford G

Abstract excerpt

RATIONALE: Endothelial dysfunction is a characteristic feature of diabetes and obesity in animal models and humans. Deficits in nitric oxide production by endothelial nitric oxide synthase (eNOS) are associated with insulin resistance, which is exacerbated by high-fat diet. Nevertheless, the meta...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22896587
DOI: 10.1161/CIRCRESAHA.112.266395
PMCID: PMC3707504

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22896587-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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