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Article

Epoxyeicosatrienoic acid agonist rescues the metabolic syndrome phenotype of HO-2-null mice.

The Journal of pharmacology and experimental therapeutics - 1 Dec 2009

Sodhi Komal, Inoue Kazuyoshi, Gotlinger Katherine H, Canestraro Martina, Vanella Luca, Kim Dong Hyun, Manthati Vijay L, Koduru Sreenivasulu Reddy, Falck John R, Schwartzman Michal L, Abraham Nader G

Abstract excerpt

Heme oxygenase (HO) and cytochrome P450 (P450)-derived epoxyeicosatrienoic acids (EETs) participate in vascular protection, and recent studies suggest these two systems are functionally linked. We examined the consequences of HO deficiency on P450-derived EETs with regard to body weight, adiposity, insulin resistance, blood pressure, and vascular function in HO-2-null mice. The HO-2-null mice were obese,...

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Identifiers

PMID: 19717790
DOI: 10.1124/jpet.109.157545
PMCID: PMC2784709

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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