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Article

Association of FXR gene variants with cholelithiasis.

Clinics and research in hepatology and gastroenterology - 1 Feb 2015

Hirobe-Jahn Satoko, Harsch Simone, Renner Olga, Richter Dominique, Müller Oliver, Stange Eduard F

Abstract excerpt

BACKGROUND AND AIM: Impairment of bile acid homeostasis is the most important risk factor of gallstone disease. Thereby the bile acid sensor farnesoid X receptor (FXR) plays a pivotal role in hepatic and intestinal bile acid metabolism. In this explorative study, the FXR gene was investigated to identify gene variants, associated with gallstone formation in a Caucasian population. METHODS: Sequencing of the FXR...

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Identifiers

PMID: 25242139
DOI: 10.1016/j.clinre.2014.07.002

Genes

FGF19

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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