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Farnesoid x receptor in human metabolism and disease: the interplay between gene polymorphisms, clinical phenotypes and disease susceptibility.

Expert opinion on drug metabolism & toxicology - 1 Apr 2015

Koutsounas Ioannis, Theocharis Stamatios, Delladetsima Ioanna, Patsouris Efstratios, Giaginis Constantinos

Abstract excerpt

INTRODUCTION: Farnesoid x receptor (FXR) belongs to the group of nuclear receptors (NRs), which regulate the expression of various genes by binding to DNA either as a monomer or a heterodimer with retinoid x receptor. AREAS COVERED: FXR affects several metabolic pathways through its specific target genes, regulating bile acid (BA) synthesis and homeostasis, glucose and lipid metabolism, also exhibiting a crucial...

Topics

Animals
Bile Acids and Salts
DNA
Female
Gene Expression Regulation
Glucose
Humans
Lipid Metabolism
Phenotype
Polymorphism, Single Nucleotide
Receptors, Cytoplasmic and Nuclear

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25553772
DOI: 10.1517/17425255.2014.999664

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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