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Article

Association of genetic variation in the NR1H4 gene, encoding the nuclear bile acid receptor FXR, with inflammatory bowel disease.

BMC research notes - 28 Aug 2012

Attinkara Ragam, Mwinyi Jessica, Truninger Kaspar, Regula Jaroslaw, Gaj Pawel, Rogler Gerhard, Kullak-Ublick Gerd A, Eloranta Jyrki J

Abstract excerpt

BACKGROUND: Pathogenesis of inflammatory bowel diseases (IBD), ulcerative colitis (UC) and Crohn's disease (CD), involves interaction between environmental factors and inappropriate immune responses in the intestine of genetically predisposed individuals. Bile acids and their nuclear receptor, FXR, regulate inflammatory responses and barrier function in the intestinal tract. METHODS: We studied the association of...

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Identifiers

PMID: 22929053
DOI: 10.1186/1756-0500-5-461
PMCID: PMC3517390

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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