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Genome-wide association meta-analysis yields 20 loci associated with gallstone disease

26 Nov 2018

Abstract excerpt

Abstract Gallstones are responsible for one of the most common diseases in the Western world and are commonly treated with cholecystectomy. We perform a meta-analysis of two genome-wide association studies of gallstone disease in Iceland and the UK, totaling 27,174 cases and 736,838 controls, uncovering 21 novel gallstone-associated variants at 20 loci. Two distinct low frequency missense variants in SLC10A2,...

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PMID: 30504769
DOI: 10.1038/s41467-018-07460-y

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