Article
DNMT3A mutations and prognostic significance in childhood acute lymphoblastic leukemia.
Leukemia & lymphoma - 1 Apr 2015
Li Weijing, Gao Chao, Cui Lei, Liu Shuguang, Zhao Xiaoxi, Zhang Ruidong, Wu Minyuan, Zheng Huyong, Deng Guoren, Li Zhigang, Zhang Quangeng
Abstract excerpt
Little is known about DNMT3A mutations in childhood acute lymphoblastic leukemia (ALL). We screened for DNMT3A mutations in exon 23 and its adjacent intron regions in diagnostic samples of 201 children with ALL. The cDNA samples from 82 patients were also sequenced to identify other mutations in the entire coding region. DNMT3A mutations were detected in exon 23 and its adjacent intron regions only in five...
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