Article
DNMT3A mutations in Chinese childhood acute myeloid leukemia.
Medicine - 1 Aug 2017
Li Weijing, Cui Lei, Gao Chao, Liu Shuguang, Zhao Xiaoxi, Zhang Ruidong, Zheng Huyong, Wu Minyuan, Li Zhigang
Abstract excerpt
BACKGROUND: DNA methyltransferase 3A (DNMT3A) mutations have been found in approximately 20% of adult acute myeloid leukemia (AML) patients and in 0% to 1.4% of children with AML, and the hotspots of mutations are mainly located in the catalytic methyltransferase domain, hereinto, mutation R882 accounts for 60%. Although the negative effect of DNMT3A on treatment outcome is well known, the prognostic significance...
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