Article
Familial and sporadic pancreatic cancer share the same molecular pathogenesis.
Familial cancer - 1 Mar 2015
Norris Alexis L, Roberts Nicholas J, Jones Siân, Wheelan Sarah J, Papadopoulos Nickolas, Vogelstein Bert, Kinzler Kenneth W, Hruban Ralph H, Klein Alison P, Eshleman James R
Abstract excerpt
Pancreatic ductal adenocarcinoma (PDAC) is nearly uniformly lethal, with a median overall survival in 2014 of only 6 months. The genetic progression of sporadic PDAC (SPC) is well established, with common somatic alterations in KRAS, p16/CDKN2A, TP53, and SMAD4/DPC4. Up to 10 % of all PDAC cases occur in families with two or more affected first-degree relatives (familial pancreatic cancer, FPC), but these cases...
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