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Article

Hereditary Pancreatic Cancer: Genetic Risk, Surveillance Strategies, and Therapeutic Implications.

International journal of molecular sciences - 18 Jul 2026

Marafioti Mariapia, Patruno Margherita, Musarra Martina, Silvestris Nicola, Portillo Funes Jessica Alejandra, Omero Fausto, Sapuppo Elena, Cianci Vincenzo, Calabrò Marco, Irrera Natasha, Briuglia Silvana, Santarpia Mariacarmela, Speranza Desirèe

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with a rising incidence and a poor prognosis that largely reflects late-stage diagnosis. Although most cases are sporadic, approximately 5-10% of PDACs occur in the context of inherited cancer susceptibility, including hereditary pancreatic cancer (HPC) syndromes and familial pancreatic cancer (FPC). Germline pathogenic variants...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42511746
DOI: 10.3390/ijms27146404
PMCID: PMC13410001

Genes

ATM
BRCA1
BRCA2
CDKN2A
PALB2
STK11
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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