Article
Familial pancreatic cancer syndromes.
Endocrinology and metabolism clinics of North America - 1 Jun 2006
Habbe Nils, Langer Peter, Sina-Frey Mercedes, Bartsch Detlef K
Abstract excerpt
Hereditary pancreatic cancer (PC) is rare and extremely heterogeneous, and it accounts for approximately 2% of all PC cases. The major component of hereditary PC is the familial pancreatic cancer syndrome. Although up to 20% of hereditary PC cases are associated with germline mutations in the BRCA2, CDKN2A, PRSS1,STKI1, or MMR genes, the major underlying gene defect(s) is still unknown. Although hereditary PC is...
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