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Article

Pancreatic Cancer: Genetics, Screening, Prevention, and Treatment.

The Surgical clinics of North America - 1 Aug 2026

Abul-Khoudoud Sami O, Hardacre Jeffrey M

Abstract excerpt

Pancreatic cancer is a highly lethal malignancy with an overall 5-year survival rate of just 13%, and its most common histologic subtype, pancreatic ductal adenocarcinoma (PDAC), carries an even poorer prognosis. Its aggressive nature is driven by complex genetic, epigenetic, and microenvironmental alterations. Key driver mutations in Kirsten rat sarcoma, cyclin-dependent kinase inhibitor 2A, TP53, and SMAD4...

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Topics

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Share to Carcinoma, Pancreatic Ductal
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42419311
DOI: 10.1016/j.suc.2026.03.009

Genes

SMAD4
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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