Article
Lack of evidence to support the association of a single IL28B genotype SNP rs12979860 with the HTLV-1 clinical outcomes and proviral load.
BMC infectious diseases - 23 Dec 2012
Sanabani Sabri Saeed, Nukui Youko, Pereira Juliana, da Costa Antonio Charlys, de Oliveira Ana Carolina Soares, Pessôa Rodrigo, Leal Fabio Eudes, Segurado Aluisio C, Kallas Esper Georges, Sabino Ester Cerdeira
Abstract excerpt
BACKGROUND: The Interleukin 28B (IL28B) rs12979860 polymorphisms was recently reported to be associated with the human T-cell leukemia virus type 1 (HTLV-1) proviral load (PvL) and the development of the HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). METHODS: In an attempt to examine this hypothesis, we assessed the association of the rs12979860 genotypes with HTLV-1 PvL levels and clinical...
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