Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of CSPG receptor LAR phosphatase in restricting axon regeneration after CNS injury.

Neurobiology of disease - 1 Jan 2015

Xu Bin, Park Dongsun, Ohtake Yosuke, Li Hui, Hayat Umar, Liu Junjun, Selzer Michael E, Longo Frank M, Li Shuxin

Abstract excerpt

Extracellular matrix molecule chondroitin sulfate proteoglycans (CSPGs) are highly upregulated in scar tissues and form a potent chemical barrier for CNS axon regeneration. Recent studies support that the receptor protein tyrosine phosphatase σ (PTPσ) and its subfamily member leukocyte common antigen related phosphatase (LAR) act as transmembrane receptors to mediate CSPG inhibition. PTPσ deficiency increased...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzofurans
Share to Biotin
Share to Dextrans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nerve Regeneration

Share to Pyramidal Tracts

Share to Receptor-Like Protein Tyrosine Phosphatases, Class 2

Share to Recovery of Function

Share to Spinal Cord Injuries

Source

Open in PubMed Open full text

Identifiers

PMID: 25220840
DOI: 10.1016/j.nbd.2014.08.030
PMCID: PMC4427014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of CSPG receptor LAR phosphatase in restricting axon regeneration after CNS injury.PMID 25220840Read ↗

Receptor tyrosine phosphatases guide vertebrate motor axons during development.Semantic proximity Read ↗

Aberrant astrocytic expression of chondroitin sulfate proteoglycan receptors in a rat model of amyotrophic lateral sclerosis.Semantic proximity Read ↗

C-terminal domain small phosphatase 1 (CTDSP1) regulates growth factor expression and axonal regenerationSemantic proximity Read ↗

Mammalian motoneuron axon targeting requires receptor protein tyrosine phosphatases sigma and delta.Semantic proximity Read ↗

NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans.Semantic proximity Read ↗

Protein phosphatase 2A (PP2A) activation promotes axonal growth and recovery in the CNS.Semantic proximity Read ↗

Widespread AAV-mediated CSPG digestion impairs functional recovery after cervical spinal cord injurySemantic proximity Read ↗

Conditional Sox9 ablation reduces chondroitin sulfate proteoglycan levels and improves motor function following spinal cord injury.Semantic proximity Read ↗

Axon Regeneration and Functional Recovery after Spinal Cord Injury is Enhanced by Allele-Specific ApoE Neuronal Action through LRP8Semantic proximity Read ↗

Injury-induced Semaphorin6C/PlexinA2 signaling drives remote neuronal apoptosis and functional impairment in the adult CNSSemantic proximity Read ↗

Desulfation of Heparan Sulfate by Sulf1 and Sulf2 Is Required for Corticospinal Tract Formation.Semantic proximity Read ↗

p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.