Article

Widespread AAV-mediated CSPG digestion impairs functional recovery after cervical spinal cord injury

2026-05-26

Abstract excerpt

<h4>ABSTRACT</h4> Spinal cord injury (SCI) disrupts long-distance communication between the brain and spinal circuits, resulting in persistent motor, sensory and autonomic dysfunction 1 . These deficits arise from the limited regenerative capacity of adult central nervous system (CNS) neurons and the presence of a growth-inhibitory extracellular environment. Among pathways that control voluntary movement, failur...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2c123515-e334-548b-addd-24cee8cd2705
DOI: 10.64898/2026.05.22.727165

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Widespread AAV-mediated CSPG digestion impairs functional recovery after cervical spinal cord injuryDOI 10.64898/2026.05.22.727165Read

PTEN knockout using retrogradely transported AAVs restores locomotor abilities in both acute and chronic spinal cord injurySemantic proximity Read

Protein phosphatase 2A (PP2A) activation promotes axonal growth and recovery in the CNS.Semantic proximity Read

Overexpressing eukaryotic elongation factor 1 alpha (eEF1A) proteins to promote corticospinal axon repair after injurySemantic proximity Read

Injury-induced Semaphorin6C/PlexinA2 signaling drives remote neuronal apoptosis and functional impairment in the adult CNSSemantic proximity Read

Recent progress and challenges in the treatment of spinal cord injurySemantic proximity Read

Inositol Polyphosphate-5-phosphatase K ( <i>Inpp5k</i> ) enhances sprouting of corticospinal tract axons after CNS traumaSemantic proximity Read

C-terminal domain small phosphatase 1 (CTDSP1) regulates growth factor expression and axonal regenerationSemantic proximity Read

Personalized Stem Cell-Based Regeneration in Spinal Cord Injury CareSemantic proximity Read

Astrocyte-selective AAV-ADAMTS4 gene therapy combined with hindlimb rehabilitation promotes functional recovery after spinal cord injurySemantic proximity Read

Role of CSPG receptor LAR phosphatase in restricting axon regeneration after CNS injury.Semantic proximity Read

Peripheral nervous system genes expressed in central neurons induce growth on inhibitory substrates.Semantic proximity Read

Human spinal interneurons repair the injured spinal cord through synaptic integrationSemantic proximity Read