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Article

Aberrant astrocytic expression of chondroitin sulfate proteoglycan receptors in a rat model of amyotrophic lateral sclerosis.

Journal of neuroscience research - 1 Feb 2018

Shijo Tomomi, Warita Hitoshi, Suzuki Naoki, Kitajima Yasuo, Ikeda Kensuke, Akiyama Tetsuya, Ono Hiroya, Mitsuzawa Shio, Nishiyama Ayumi, Izumi Rumiko, Aoki Masashi

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. Progressive and systemic loss of motor neurons with gliosis in the central nervous system (CNS) is a neuropathological hallmark of ALS. Chondroitin sulfate proteoglycans (CSPGs) are the major components of the extracellular matrix of the mammalian CNS, and they inhibit axonal regeneration physically by participating to form the glial scar....

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PMID: 28752900
DOI: 10.1002/jnr.24127

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SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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