Article
NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans.
Nature neuroscience - 11 Mar 2012
Dickendesher Travis L, Baldwin Katherine T, Mironova Yevgeniya A, Koriyama Yoshiki, Raiker Stephen J, Askew Kim L, Wood Andrew, Geoffroy Cédric G, Zheng Binhai, Liepmann Claire D, Katagiri Yasuhiro, Benowitz Larry I, Geller Herbert M, Giger Roman J
Abstract excerpt
In the adult mammalian CNS, chondroitin sulfate proteoglycans (CSPGs) and myelin-associated inhibitors (MAIs) stabilize neuronal structure and restrict compensatory sprouting following injury. The Nogo receptor family members NgR1 and NgR2 bind to MAIs and have been implicated in neuronal inhibition. We found that NgR1 and NgR3 bind with high affinity to the glycosaminoglycan moiety of proteoglycans and...
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