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Article

Mammalian motoneuron axon targeting requires receptor protein tyrosine phosphatases sigma and delta.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 31 May 2006

Uetani Noriko, Chagnon Mélanie J, Kennedy Timothy E, Iwakura Yoichiro, Tremblay Michel L

Abstract excerpt

The leukocyte common antigen-related (LAR) subfamily of receptor protein tyrosine phosphatases (RPTPs), LAR, RPTP-sigma, and RPTP-delta, regulate neuroendocrine development, axonal regeneration, and hippocampal long-term potentiation in mammals. In Drosophila, RPTPs are required for appropriate axon targeting during embryonic development. In contrast, deletion of any one of the three LAR-RPTP family members in...

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Identifiers

PMID: 16738228
DOI: 10.1523/JNEUROSCI.0386-06.2006
PMCID: PMC6675220

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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