Article
The MLKL kinase-like domain dimerization is an indispensable step of mammalian MLKL activation in necroptosis signaling.
Cell death & disease - 22 Jun 2021
Zhang Yu, Liu Jia, Yu Dandan, Zhu Xinxin, Liu Xiaoyan, Liao Jun, Li Sheng, Wang Huayi
Abstract excerpt
MLKL phosphorylation by RIP3 is the commitment step of necroptosis execution, which could induce MLKL activation featured as MLKL monomer-oligomer transition. Here, we reported that the dimerization of the MLKL kinase-like domain was the direct consequence of RIP3 triggered MLKL-phosphorylation. Two inter-dimer interfaces were found in the crystal structure of human MLKL. Mutations destroying both interfaces...
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