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Article

Anxiety- and depression-like phenotype of hph-1 mice deficient in tetrahydrobiopterin.

Neuroscience research - 1 Dec 2014

Nasser Arafat, Møller Lisbeth B, Olesen Jess H, Konradsen Refsgaard Louise, Konradsen Louise S, Andreasen Jesper T

Abstract excerpt

Decreased tetrahydrobiopterin (BH4) biosynthesis has been implicated in the pathophysiology of anxiety and depression. The aim of this study was therefore to characterise the phenotype of homozygous hph-1 (hph) mice, a model of BH4 deficiency, in behavioural tests of anxiety and depression as well as determine hippocampal monoamine and plasma nitric oxide levels. In the elevated zero maze test, hph mice displayed...

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Source

Identifiers

PMID: 25218564
DOI: 10.1016/j.neures.2014.08.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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