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Article

Increased anxiety of mice lacking the serotonin1A receptor.

Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1998

Parks C L, Robinson P S, Sibille E, Shenk T, Toth M

Abstract excerpt

Brain serotonin (5-HT) has been implicated in a number of physiological processes and pathological conditions. These effects are mediated by at least 14 different 5-HT receptors. We have inactivated the gene encoding the 5-HT1A receptor in mice and found that receptor-deficient animals have an increased tendency to avoid a novel and fearful environment and to escape a stressful situation, behaviors consistent...

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Identifiers

PMID: 9724773
DOI: 10.1073/pnas.95.18.10734
PMCID: PMC27964

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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