Enhanced aggressive behavior in mice lacking 5-HT1B receptor.

doi:10.1126/science.8091214

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Article

Enhanced aggressive behavior in mice lacking 5-HT1B receptor.

Science (New York, N.Y.) - 23 Sept 1994

Saudou F, Amara D A, Dierich A, LeMeur M, Ramboz S, Segu L, Buhot M C, Hen R

Abstract excerpt

The neuromodulator serotonin (5-hydroxytryptamine, 5-HT) has been associated with mood disorders such as depression, anxiety, and impulsive violence. To define the contribution of 5-HT receptor subtypes to behavior, mutant mice lacking the 5-HT1B receptor were generated by homologous recombinatio...

Topics

Aggression
Animals
Brain Chemistry
Chimera
Female
Indoles
Male
Mice
Motor Activity
Mutation
Pindolol
Receptor, Serotonin, 5-HT1B
Receptors, Serotonin
Recombination, Genetic
Serotonin Receptor Agonists

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