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Article

Enhanced aggressive behavior in mice lacking 5-HT1B receptor.

Science (New York, N.Y.) - 23 Sept 1994

Saudou F, Amara D A, Dierich A, LeMeur M, Ramboz S, Segu L, Buhot M C, Hen R

Abstract excerpt

The neuromodulator serotonin (5-hydroxytryptamine, 5-HT) has been associated with mood disorders such as depression, anxiety, and impulsive violence. To define the contribution of 5-HT receptor subtypes to behavior, mutant mice lacking the 5-HT1B receptor were generated by homologous recombination. These mice did not exhibit any obvious developmental or behavioral defects. However, the hyperlocomotor effect of...

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PMID: 8091214
DOI: 10.1126/science.8091214

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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