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Article

Behavioural phenotype of histamine H4 receptor knockout mice: Focus on central neuronal functions.

Neuropharmacology - 1 Mar 2017

Sanna Maria Domenica, Ghelardini Carla, Thurmond Robin L, Masini Emanuela, Galeotti Nicoletta

Abstract excerpt

The functional expression of H4 receptors (H4R) within neurons of the central nervous system has been recently reported, but their role is poorly understood. The present study aims to elucidate the role of neuronal H4R by providing the first description of the behavioural phenotype of H4R-deficient (H4R knockout, H4R-KO) mice. Mice lacking H4R underwent behavioural studies to evaluate locomotor activity, pain...

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PMID: 27899280
DOI: 10.1016/j.neuropharm.2016.11.023

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