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Article

Evaluation of the emotional phenotype and serotonergic neurotransmission of fatty acid amide hydrolase-deficient mice.

Psychopharmacology - 1 Mar 2011

Cassano Tommaso, Gaetani Silvana, Macheda Teresa, Laconca Leonardo, Romano Adele, Morgese Maria Grazia, Cimmino Concetta Stefania, Chiarotti Flavia, Bambico Francis R, Gobbi Gabriella, Cuomo Vincenzo, Piomelli Daniele

Abstract excerpt

RATIONALE: By enhancing brain anandamide tone, inhibitors of fatty acid amide hydrolase (FAAH) induce anxiolytic-like effects in rodents and enhance brain serotonergic transmission. Mice lacking the faah gene (FAAH(-/-)) show higher anandamide levels. However, their emotional phenotype is still debated and their brain serotonergic tone remained unexplored. OBJECTIVES AND METHODS: In this study, we tested...

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Source

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Identifiers

PMID: 21042794
DOI: 10.1007/s00213-010-2051-0
PMCID: PMC3045513

Genes

FAAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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