Article
Genome-wide genetic variations are highly correlated with proximal DNA methylation patterns.
Genome research - 1 Aug 2012
Qu Wei, Hashimoto Shin-ichi, Shimada Atsuko, Nakatani Yoichiro, Ichikawa Kazuki, Saito Taro L, Ogoshi Katsumi, Matsushima Kouji, Suzuki Yutaka, Sugano Sumio, Takeda Hiroyuki, Morishita Shinichi
Abstract excerpt
5-methyl-cytosines at CpG sites frequently mutate into thymines, accounting for a large proportion of spontaneous point mutations. The repair system would leave substantial numbers of errors in neighboring regions if the synthesis of erased gaps around deaminated 5-methyl-cytosines is error-prone. Indeed, we identified an unexpected genome-wide role of the CpG methylation state as a major determinant of proximal...
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