Article

Cytosine methylation affects the mutability of neighbouring nucleotides in human, Arabidopsis, and rice

2019-09-16

Abstract excerpt

<h4>ABSTRACT</h4> Methylated cytosines deaminate at higher rates than unmethylated cytosines and the lesions they produce are repaired less efficiently. As a result, methylated cytosines are mutational hotspots. Here, combining rare polymorphism and base-resolution methylation data in humans, Arabidopsis thaliana , and rice ( Oryza sativa ), we present evidence that methylation state affects mutation dynamics n...

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Literature Corpus work: 08f387fa-e15e-50c6-999e-295e82918d7f
DOI: 10.1101/764753

Open publication

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