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Article

Effects of metabolic acidosis on intracellular pH responses in multiple cell types.

American journal of physiology. Regulatory, integrative and comparative physiology - 15 Dec 2014

Salameh Ahlam Ibrahim, Ruffin Vernon A, Boron Walter F

Abstract excerpt

Metabolic acidosis (MAc), a decrease in extracellular pH (pHo) caused by a decrease in [HCO3 (-)]o at a fixed [CO2]o, is a common clinical condition and causes intracellular pH (pHi) to fall. Although previous work has suggested that MAc-induced decreases in pHi (ΔpHi) differ among cell types, what is not clear is the extent to which these differences are the result of the wide variety of methodologies employed...

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Identifiers

PMID: 25209413
DOI: 10.1152/ajpregu.00154.2014
PMCID: PMC4269672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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