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Article

Interplay between a cytosolic and a cell surface carbonic anhydrase in pH homeostasis and acid tolerance of Leishmania.

Journal of cell science - 15 Feb 2017

Pal Dhiman Sankar, Abbasi Mazharul, Mondal Dipon Kumar, Varghese Binitha Anu, Paul Ritama, Singh Shalini, Datta Rupak

Abstract excerpt

Leishmania parasites have evolved to endure the acidic phagolysosomal environment within host macrophages. How Leishmania cells maintain near-neutral intracellular pH and proliferate in such a proton-rich mileu remains poorly understood. We report here that, in order to thrive in acidic conditions, Leishmania major relies on a cytosolic and a cell surface carbonic anhydrase, LmCA1 and LmCA2, respectively. Upon...

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Identifiers

PMID: 28062849
DOI: 10.1242/jcs.199422

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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